Heart rate variability in patients with overactive bladder or stress urinary incontinence. (2024)

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The goal of the study is to investigate the difference between heart rate variability in patients with overactive bladder and patients with stress incontinence without overactive bladder, and also the difference in heart rate variability with empty…

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Ethical review

Approved WMO

Status

Completed

Health condition type

Bladder and bladder neck disorders (excl calculi)

Study type

Observational non invasive

ID

NL-OMON36299

Source

ToetsingOnline

Brief title

HRV in OAB and SUI

Synonym

overactive bladder, urgency

Research involving

Human

Sponsors and support

Primary sponsor :

Universitair Medisch Centrum Utrecht

Source(s) of monetary or material Support :

Ministerie van OC&W

Intervention

Keyword :

autonomic nerve system, heart rate variability, overactive bladder, stress urinary incontinence

Outcome measures

Primary outcome

Difference in LF/HF ratio between patients with IOAB and SUI

Difference in LF/HF between full and empty bladder in patients in both groups

Secondary outcome

Difference in total power (TP), SDNN, RMSSD, VLF, HF and LF between patients

with IOAB and SUI

Difference in total power (TP), SDNN, RMSSD, VLF, HF and LF between full and

empty bladder in patients in both groups

Background summary

Symptoms of overactive bladders syndrome are: frequency, urgency, nyctuia, with
or without incontinence. The cause of idiopathic overactive bladder syndrome is
unknown. There are indications pointing to a dysbalance of the autonomic nerve
system. Previous studies have shown an overactivity of the parasympathethic
system with empty bladder and overactivity of the sympathethic system with full
bladder. In patients with stress incontinence there was a lack of sympathethic
activity with full bladder.
The heart rate normally varies from beat to beat en the extent of variability
reflects cardiac condition, but also the balance of the autonomous nerve
system. Variability of the heart rate can be calculated with special software
from a simple ECG.

Study objective

The goal of the study is to investigate the difference between heart rate
variability in patients with overactive bladder and patients with stress
incontinence without overactive bladder, and also the difference in heart rate
variability with empty bladder and full bladder in these two groups.

Study design

The study will be performed in female patients diagnosed with overactive
bladder or stress incontinence.
A ten minute ECG will be performed in rest with empty bladder (just after
voiding). Then the patient will be offered some drinks en when she has the
feeling of a full bladder (urge to void), the second ECG will be recorded.
Imediately afterwards the patient is allowed to void and the voided volume will
be measured.
The ECG will be analysed according to the time domain method and the frequency
domain method. The following parameters will be determined: total power, SDNN,
RMSSD, the very low frequency (VLF) band, thelow frequency (LF) band and
thehigh frequency (HF) band, The ration between LF and HF is a measure of
autonomic nerve system balance.

Study burden and risks

During one visits 2 ECG's will be recorded. The time span between the 2 ECG's
will depend on the speed of bladder filling. In between the measurements the
patient is free to do an activity of choice. The ECG is not burdensome,
invasive or harmful. Use of caffeine containing drinks and physical exercise
are discouraged before the measurements.

Public

Universitair Medisch Centrum Utrecht

heidelberglaan 100
3584 cx utrecht
NL

Scientific

Universitair Medisch Centrum Utrecht

heidelberglaan 100
3584 cx utrecht
NL

Listed location countries

Netherlands

Age

Adults (18-64 years)

Elderly (65 years and older)

Inclusion criteria

Female sex
Age 18 - 75 years
Diagnosis of idiopathic overactive bladder or stress incontinence

Exclusion criteria

Antimuscarinic medication
Neurologic disease
cardiac disease
Medication influencing heart rate
Pregnancy
Urinary tract infection

Design

Study type :

Observational non invasive

Intervention model

:

Other

Allocation :

Non-randomized controlled trial

Masking :

Open (masking not used)

Control :

Active

Primary purpose :

Basic science

Recruitment

NL

Recruitment status

:

Completed

Start date (anticipated) :

Enrollment :

60

Type :

Actual

Approved WMO

Date :

Application type :

First submission

Review commission :

METC Universitair Medisch Centrum Utrecht (Utrecht)

Approved WMO

Date :

Application type :

Amendment

Review commission :

METC Universitair Medisch Centrum Utrecht (Utrecht)

Followed up by the following (possibly more current) registration

No registrations found.

Other (possibly less up-to-date) registrations in this register

No registrations found.

In other registers

Register ID
CCMO NL33014.041.10
Heart rate variability  in  patients with overactive bladder or stress urinary incontinence. (2024)

FAQs

Heart rate variability in patients with overactive bladder or stress urinary incontinence.? ›

Results: Heart rate variability parameters did not change significantly during bladder filling in women with stress urinary incontinence.

Can heart problems cause urinary incontinence? ›

It's not uncommon for heart issues to be related to urologic conditions. In fact, more than half of all people with heart failure have issues with urinary incontinence.

What is the hallmark symptom of the overactive bladder? ›

Urgency, the hallmark of OAB, is defined as the sudden compelling desire to urinate, a sensation that is difficult to defer.

What is the difference between stress urinary incontinence and overactive bladder? ›

Both conditions have some things in common, and sometimes a person can have both. Still, they're not quite the same thing. OAB involves the urge to urinate, whereas urinary incontinence involves involuntary urination.

What are the risk factors for stress incontinence? ›

Loss of support from pelvic floor musculature and connective tissue - loss of support can originate from connective tissue disorders, chronic cough, obesity, pelvic floor trauma after vagin* delivery, pregnancy, menopause, constipation, heavy lifting, and smoking. Neuromuscular damage from previous pelvic surgeries.

Does frequent urination have anything to do with heart problems? ›

While heart failure can cause increased urination in general, it's particularly common at night. If you find yourself getting up several times a night to use the restroom, you could be suffering from nocturia.

Does your heart rate increase when you pee? ›

When your bladder is full, your blood pressure and heart rate are higher. When you empty your bladder during urination, your blood pressure and heart rate drop. This drop causes your blood vessels to widen, or dilate.

What calms down an overactive bladder? ›

The following strategies may help:
  • Stop what you're doing and stay put. Stand quietly or sit down, if possible. ...
  • Squeeze your pelvic floor muscles quickly several times (Kegels). ...
  • Relax the rest of your body. ...
  • Concentrate on suppressing your urge to pee.
  • Wait until the urge goes away.
  • Walk to the bathroom at a normal pace.

What are the red flags of an overactive bladder? ›

Refer to secondary care if there are any red flag symptoms: haematuria, bladder pain, recurrent urinary tract infection.

What neurological conditions cause overactive bladder? ›

Millions of Americans have neurogenic bladder. Neurogenic bladder is the name given to a number of urinary conditions in people who lack bladder control due to a brain, spinal cord or nerve problem. This nerve damage can be the result of diseases such as multiple sclerosis (MS), Parkinson's disease or diabetes.

Does drinking more water help bladder leakage? ›

Drink plenty of water

Drink 6 to 8 glasses of fluid a day (but no more) unless your doctor advises you otherwise. Many people with urinary incontinence avoid drinking fluids, as they feel it causes more problems. However, limiting your fluid intake makes incontinence worse, because it reduces your bladder's capacity.

What is the best medicine for overactive bladder? ›

Medications
  • Fesoterodine (Toviaz).
  • Mirabegron (Myrbetriq).
  • Oxybutynin, which can be taken as a pill (Ditropan XL) or used as a skin patch (Oxytrol) or gel (Gelnique).
  • Solifenacin (Vesicare).
  • Tolterodine (Detrol).
  • Trospium.
Mar 2, 2024

What is very bad stress incontinence? ›

If you have stress incontinence, you may notice that you accidentally leak urine when you move or perform certain activities. The urine leakage may be an occasional drop or dribble if the condition is mild. In severe cases, you may leak a stream of urine. Stress incontinence is different from overactive bladder (OAB).

What aggravates stress incontinence? ›

Stress incontinence that is mild can progress to moderate or severe. This is most likely to happen if you gain a lot of weight (or don't lose excess weight). Symptoms may worsen if you continue to smoke or don't take other steps to manage the condition.

What are the neurological causes of stress incontinence? ›

Neurological disorders.

Multiple sclerosis, Parkinson's disease, a stroke, a brain tumor or a spinal injury can interfere with nerve signals involved in bladder control, causing urinary incontinence.

Why do I suddenly have stress incontinence? ›

Stress incontinence happens when certain muscles and other tissues linked to urinating weaken. These include the muscles that support the urethra, called the pelvic floor muscles, and the muscles that control the release of urine, called the urinary sphincter. The bladder expands as it fills with urine.

How does heart disease affect the urinary system? ›

When the heart is unable to pump forcefully, the amount of blood it ejects with each contraction drops. This reduces the amount of blood that passes through the kidneys, causing urine and waste output to drop. Because salt isn't eliminated well, fluid may build up, causing heart failure to worsen.

Can congestive heart failure cause bladder issues? ›

Some of the symptoms and treatments of this condition can contribute to bladder and bowel problems.

Why would I suddenly become incontinent? ›

Incontinence can happen for many reasons, including urinary tract infections, vagin*l infection or irritation, or constipation. Some medications can cause bladder control problems that last a short time. When incontinence lasts longer, it may be due to: Weak bladder or pelvic floor muscles.

What diseases cause urinary incontinence? ›

Urinary stones — hard, stonelike masses that form in the bladder — sometimes cause urine leakage. Neurological disorders. Multiple sclerosis, Parkinson's disease, a stroke, a brain tumor or a spinal injury can interfere with nerve signals involved in bladder control, causing urinary incontinence.

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